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. 2015 Sep 15;142(18):3178–3187. doi: 10.1242/dev.123851

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© 2015. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — Pharmacology of hPSC-derived cortical networks. (A-C) Synchronised firing is blocked by the AMPA receptor antagonist CNQX and returns after washout of CNQX. (D-F) NMDA receptor antagonist APV blocks all synchronous activity. Synchronised transients return after washout of APV. (G-I) In the presence of the GABA-A receptor agonist muscimol, synchronised transients were blocked, but returned after washout. (J-L) GABA-B receptor agonist R-baclofen blocked synchronised activity. Synchronous transients returned after washout. (M,N) There was no change in synchronised firing in the presence of GABA-A receptor antagonist bicuculline.