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. 2015 Sep 15;142(18):3178–3187. doi: 10.1242/dev.123851

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© 2015. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 6. — Plasticity in iPSC-derived cortical neural networks. (A) Synchronised activity in day-145 CRL iPSC-derived cortical cultures. (B) 50 min after a 5-min treatment with 100 µM glycine and 0 mM Mg²⁺, cultures exhibited a marked change in their pattern of synchronised bursting. (C,D) Synchronised activity before (C) and 50 min after (D) treatment with APV during a 5-min pulse with 100 µM glycine and 0 mM Mg²⁺ solution. (E) The amplitude of synchronised transients showed a significant increase (P<0.01, Student's t-test) after glycine and 0 mM Mg²⁺ treatment, and no significant change with APV/glycine/0 mM Mg²⁺ treatment. (F) Significant increase (P<0.01, Student's t-test) in the frequency of bursts after glycine/0 mM Mg²⁺ treatment, and no significant change after APV/glycine/0 mM Mg²⁺ treatment.