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. Author manuscript; available in PMC: 2016 Feb 27.
Published in final edited form as: Nature. 2015 Jul 20;524(7566):481–484. doi: 10.1038/nature14859

Extended Data Figure 1. Proteostatic crosstalk between mitochondria and the cytosol.

Extended Data Figure 1

(a) Suppression of ρ°-lethality in the yme1Δ, atp1Δ, tom70Δ and mgr2Δ mutants by anti-degenerative genes on YPD medium supplemented with ethidium bromide that eliminates mtDNA. (b) Schematic depiction of the cytosolic anti-degenerative proteostatic network that suppresses mPOS. (c) Synthetic growth defect between yme1Δ and the disruption of anti-degenerative genes (PBP1, RPL40A, SSB1 and POC4) and other genes affecting cytosolic proteostasis (DHH1, BLM10 and RPN4). Cells were grown on YPD medium and incubated at 37°C.