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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: J Neural Eng. 2015 Sep 8;12(5):056015. doi: 10.1088/1741-2560/12/5/056015

Figure 2.

Figure 2

Action potentials (left) in single-compartment lumped models (SCMs) of neurons with constant or frequency-dependent membrane capacitance (right). (a) 10 kHz sinusoidal stimulation of a SCM with HH ion channels and a membrane capacitance that was either constant (i.e., cdc or c∞) or declined with increasing frequency (right). Vm is the transmembrane voltage, and the arrow indicates the onset of stimulation. (b) Intracellular monophasic pulse stimulation (i) of a SCM with MRG ion channels found in the node of Ranvier of a myelinated axon. The pulse was 100 μs in duration. Note that the repetitive action potentials following a single stimulus are the result of implementing in a single compartment model membrane dynamics that were originally parameterized to represent a node of Ranvier in a multi-compartment cable model. The experimental data are from (Takashima and Schwan, 1974).