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Rat lung microvascular endothelial cell (RLMEC) monolayers transfected with active caspase-3 peptide showed significant increase in permeability compared to the untreated control monolayers (*p<0.05). Active caspase-3 transfected monolayers when pre-treated with SB216763 showed no significant effect in decreasing the hyperpermeability induced by active caspase-3 transfected RLMEC monolayers.
