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Representative compounds of the four major chemical classes of exogenous cannabinoid ligands. Note that the classical cannabinoid Δ9-THC is a relatively low efficacy partial agonist at cannabinoid receptors, the non-classical cannabinoid CP 55,940 and the aminoalkylindole JWH-018 are both full agonists at CB1 receptors, while the 1,5 biarylpyrazole rimonabant functions as an antagonist/inverse agonist at cannabinoid receptors.
