Table 4. Proliferative index of Ki-67 and flow cytometry analysis in OSCC, para-tumor tissue and normal mucosa.
| Groups | Number | PI of Ki-67 #/% | Aneuploidy | Aneuploidy rate/% | SPF #/% | PI #/% |
|---|---|---|---|---|---|---|
| T | 50 | 31.07±4.39a | 31 | 62b | 27.51±6.69c | 30.27±6.59d |
| P1 | 50 | 40.10±6.44a | 27 | 54b | 25.96±6.56c | 28.55±6.44d |
| P2 | 50 | 18.61±1.91a | 14 | 28b | 21.50±5.72c | 23.72±5.29d |
| P3 | 50 | 13.96±3.91a | 8 | 16b | 17.60±5.79c | 19.63±5.80d |
| P4 | 50 | 7.11±2.76a , e | 8 | 16b | 14.26±5.84c | 16.12±5.69d |
| N | 20 | 6.74±3.32a , e | 0 | 0b | 8.39±1.93c | 10.85±2.04d |
OSCC, oral squamous cell carcinoma; PI, proliferative index; SPF, S-phase fraction. T, centre of the tumor; P1, 0–0.5 cm to tumor boundary; P2, 0.5–1 cm to tumor boundary; P3, 1–1.5 cm to tumor boundary; P4, 1.5–2 cm to tumor boundary; N, normal mucosa.
#Mean±Standard deviation.
a
Significant statistic differences among the groups (P<0.001).
b,c,d
Significant differences between T, P1 and P2, P3, P4, N groups (P<0.001), and between N with T, P1, P2, P3 and P4 groups (P<0.001), no difference was found between T and P1 groups (P>0.05).
e
There were no statistical difference between P4 and N groups (P>0.05).