Table 1. Patient and graft characteristics.
Number of patients | 65 |
| |
Age in years, median (range) | 46 (6-68) |
| |
Weight in kilograms, median (range) | 80.8 (22.1-124.3) |
| |
Male | 40 (61%) |
| |
Recipient CMV positive | 27 (42%) |
| |
Histology | |
Follicular lymphoma/CLL | 20 (31%) |
Large cell/mantle cell lymphoma | 22 (34%) |
Hodgkin's lymphoma | 23 (35%) |
| |
Pre-transplant hematologic function | |
White blood cell count, median (range) | 5,500 × 109/L (0.3-24) |
Absolute neutrophil count, median (range) | 3,600 × 109/L (0.2-15) |
Platelet count, median (range) | 171 × 109/L (13-422) |
| |
Number of UCB units in the graft | |
One UCB unit | 9 (14%) |
Two UCB units | 56 (86%) |
| |
HLA matching to recipients | |
6/6 or 6/6 + 6/6 | 3 (5%) |
6/6 + 5/6 | 3 (5%) |
5/6 or 5/6 + 5/6 | 14 (21%) |
5/6 + 4/6 | 20 (31%) |
4/6 or 4/6 + 4/6 | 25 (38%) |
| |
Sex match (donor-recipient)* | |
Matching | 19 (29%) |
Mismatching | 46 (71%) |
| |
ABO blood type (donor-recipient)* | |
Matched | 10 (15%) |
Mismatched | 54 (83%) |
Missing | 1 (2%) |
| |
Total nucleated cell dose (× 107/kg), median (range) | 3.3 (2.0-6.2) |
| |
CD34+ cell dose (× 105/kg), median (range) | 4.4 (0.7-14.3) |
| |
CD3+ cell dose (× 107/kg), median (range) | 1.4 (0.4-3.0) |
CMV, cytomegalovirus; CLL, chronic lymphocytic leukemia; UCB umbilical cord blood; HLA, human leukocyte antigen; kg, kilogram.
For recipients of two UCB units were considered mismatched if at least one of the units was mismatched.