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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Science. 2015 Apr 2;348(6234):581–585. doi: 10.1126/science.aaa4535

Fig. 2. Thumb-to-palm interactions between adjacent Cmr4 subunits form the Cmr backbone.

Fig. 2

(A) The Cmr4 backbone subunits (other subunits have been removed for clarity), form a helical arrangement by interaction of a thumb-like density from one subunit with the palm of the subunit above. This layout is strikingly similar to the Cas7 subunits (PDB 1VY9) (12) within E. coli Cascade (inset). (B) Homology model of Cmr4 (right) and the Cmr4 helical oligomer (left) shows the Cmr4 thumbs easily accommodate the β-hairpin extension (C) Close-up view of Cmr4.2 and 4.3 showing that the β-hairpin of Cmr4 (dark blue) associates with the α1 helix (red) of the neighboring Cmr4 subunit.