. Author manuscript; available in PMC: 2015 Sep 25.

Published in final edited form as: Eur J Pharm Sci. 2011 Sep 21;44(4):522–533. doi: 10.1016/j.ejps.2011.09.014

Table 6.

Yield, content and dissolution behavior of fluticasone and albuterol nanoparticle agglomerates (values = average ± S.D., n = 3).

Characteristics	Formulations
	Fluticasone NA^a	Albuterol NA^b	Flu/Albu combination ^c
	Fluticasone NA^a	Albuterol NA^b	Fluticasone	Albuterol
Process yield of lyophilized NA (%)	86 ± 7	96 ± 2	90 ± 3
% Drug content of Flu & Albu in the lyophilized NA	92 ± 5	85.3 ± 7	90 ± 3	82 ± 6
Q_8h^d NP	96 ± 1	100 ± 0.4	n/a	n/a
Q_8h NA	75 ± 7	100 ± 8	73 ± 10	100 ± 6

Fluticasone NC = 1: 0.05: 0.1: 1; Flu: Lec: PVP K90: Leu

Albuterol NC = 1: 1.5; Albu: Leu

Flu/Albu combination = 2: 1; Flu: Albu

Q8h = % Fluticasone (Flu) and albuterol (Albu) dissolved after 8 hours.