Table 1.
Comparison between mouse models of psychiatric disease
| Feature | Calcineurin knockout | DN-DISC1 |
|---|---|---|
| Promoter | αCaMKII | αCaMKII |
| Background strain | C57BL/6 [3] | C57BL/6N [14] |
| Gross brain morphology | No change [3] | No change [14] |
| Noncognitive behaviors | ||
| Locomotion | ↑ [3] | ↑ [14] |
| Anxiety | ↓ [3] | No change [14] |
| FST immobility | ↓ [3] | ↑ [14] |
| Amphetamine response | No change [4] | ↑ [17] |
| Cognitive behaviors | ||
| Prepulse inhibition | ↓ [4] | ↓ [14] |
| Reference memory | No change [3] | No change [14] |
| Social interaction | ↓ [4] | ↓ [18] |
| Working memory | ↓ [3] | Unknown |
| Neurophysiology | ||
| Ripple frequency | No change [5] | No change |
| Ripple occurrence | ↑ [5] | ↑ |
| Ripple power | ↑ [5] | ↑ |
| Theta frequency | No change [5] | No change |
| Theta power | No change [5] | No change |
| Gamma frequency | No change [5] | No change |
| Gamma power | No change [5] | No change |
Behavioral comparison of forebrain-specific calcineurin knockout and DN-DISC1 animals shows several key similarities including impaired prepulse inhibition and decreased social interaction. Neurophysiological phenotypes associated with cognition are also similarly affected with specific changes in ripple parameters but not theta or gamma.
Figures in brackets are the corresponding references.