Table 1.
Baseline Demographic and Risk Factor Profile According to Age
| Variable | ≥75, n = 494 | <75, n = 2,526 | P-Value |
|---|---|---|---|
| Age, mean ± SD | 79.9 ± 3.8 | 60.1 ± 8.4 | <.001 |
| Male, n (%) | 268 (54.3) | 1,634 (64.7) | <.001 |
| Race and ethnicity, n (%) | |||
| Non-Hispanic white | 288 (58.3) | 1,250 (49.5) | <.001 |
| Hispanic | 163 (33.0) | 753 (29.8) | |
| Black | 31 (6.3) | 461 (18.3) | |
| Other or multiple | 12 (2.4) | 62 (2.5) | |
| Medical history, n (%) | |||
| Current smoking | 26 (5.3) | 591 (23.4) | <.001 |
| Hypertension | 384 (77.7) | 1,804 (71.4) | .004 |
| Diabetes mellitus | 133 (26.9) | 973 (38.5) | <.001 |
| Hyperlipidemia | 231 (46.8) | 1,240 (49.1) | .34 |
| Prior subcortical stroke or transient ischemic attacka | 70 (14.2) | 378 (15.0) | .65 |
| Ischemic heart disease | 51 (10.3) | 266 (10.5) | .89 |
| Family history of stroke | 128 (27.1) | 741 (31.1) | .08 |
| Selected laboratory values, mean ± SD | |||
| Estimated glomerular filtration rate | 66.0 ± 14.7 | 83.0 ± 18.3 | <.001 |
| Random glucose, mg/dLa | 114.5 ± 37.8 | 127.8 ± 57.5 | <.001 |
| Glycosylated hemoglobin, %b | 7.3 ± 1.4 | 8.4 ± 2.3 | <.001 |
| Total cholesterol, mg/dLa | 182.0 ± 40.8 | 189.1 ± 48.2 | .001 |
| Low-density lipoprotein cholesterol, mg/dLa | 106.8 ± 34.7 | 113.4 ± 40.7 | <.001 |
| High-density lipoprotein cholesterol, mg/dLa | 49.6 ± 20.9 | 44.6 ± 17.8 | <.001 |
| Triglycerides, mg/dLa | 137.5 ± 76.7 | 169.8 (119.5) | <.001 |
| Magnetic resonance imaging and magnetic resonance angiography findings, n (%) | |||
| Multiple subcortical infarcts | 218 (44.5) | 972 (38.7) | .02 |
| White matter hyperintensities | |||
| None to mild | 131 (27.2) | 1,365 (54.7) | <.001 |
| Moderate | 116 (19.9) | 668 (26.8) | |
| Severe | 185 (38.4) | 464 (18.6) | |
| Intracranial stenosis >50% | |||
| Anterior circulation | 44 (9.5) | 225 (9.5) | .99 |
| Posterior circulation | 67 (14.4) | 245 (10.3) | .009 |
| Functional status | |||
| Barthel Index, mean ± SDc | 93.1 ± 12.7 | 95.9 ± 9.0 | <.001 |
| Modified Rankin Scale score 0–1, n (%)d | 322 (65.2) | 1,689 (66.9) | .47 |
| Depressed, n (%) | 31 (13.1) | 267 (22.8) | .001 |
| Cognitive Abilities Screening Instrument score >90, n (%)a,e | 139 (28.8) | 1,189 (47.6) | <.001 |
a
Missing data.
b
Participants with diabetes mellitus only.
c
Range 0 to 100, higher scores indicating better functional ability.
d
Normal to near-normal recovery.
e
Range 0 to 100, higher scores indicating better cognitive function.
SD = standard deviation.