Table 3.
Safety of Lowering Systolic Blood Pressure (SBP) According to Age and Treatment Group
| Variable | ≥75 |
<75 |
P-Value | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Overall, (n = 494) | Higher Target, n = 246 | Lower Target, n = 248 | P-Value | Overall, n = 2,526 | Higher Target, n = 1,273 | Lower Target, n = 1,253 | P-Value | ||
| Participants with ≥1 episodes of postural hypotension recorded during trial, n (%) | 290 (59) | 159 (65) | 131 (53) | .008 | 1,497 (59) | 785 (62) | 712 (57) | .01 | .82 |
|
| |||||||||
| Symptoms possibly associated with lowering SBP (ever reported), n (%) | |||||||||
|
| |||||||||
| Unsteadiness when standing | 159 (32) | 77 (33) | 82 (34) | .72 | 571 (23) | 278 (23) | 293 (24) | .36 | <.001 |
|
| |||||||||
| Blurred vision when standing | 33 (7) | 19 (8) | 14 (6) | .34 | 155 (6) | 84 (7) | 71 (6) | .32 | .64 |
|
| |||||||||
| Dizziness when standing | 104 (21) | 51 (22) | 53 (22) | .90 | 524 (21) | 253 (21) | 271 (22) | .29 | .86 |
|
| |||||||||
| Lightheadedness when standing | 76 (15) | 45 (19) | 31 (13) | .07 | 382 (15) | 191 (16) | 191 (16) | .88 | .87 |
|
| |||||||||
| Palpitations when standing | 18 (5) | 4 (2) | 14 (17) | .03 | 77 (3) | 44 (4) | 33 (3) | .23 | .48 |
|
| |||||||||
| Serious complications of hypotension, n (% per person-year) | 7 (0.39) | 2 (0.23) | 5 (0.53) | .29 | 31 (0.32) | 13 (0.27) | 18 (0.37) | .36 | .67 |
|
| |||||||||
| Orthostatic syncope | 3 (0.17) | 1 (0.11) | 2 (0.21) | .58 | 13 (0.13) | 4 (0.08) | 9 (0.18) | .18 | .73 |
|
| |||||||||
| Stroke associated with hypotension | 1 (0.06) | 0 (0) | 1 (0.11) | >.99 | 2 (0.02) | 1 (0.02) | 1 (0.02) | .99 | .44 |
|
| |||||||||
| Myocardial infarction associated with hypotension | 0 (0) | 0 (0) | 0 (0) | N/A | 0 (0) | 0 (0) | 0 (0) | N/A | N/A |
|
| |||||||||
| Fall with injury secondary to hypotension | 1 (0.06) | 0 (0) | 1 (0.11) | >.99 | 2 (0.02) | 0 (0) | 2 (0.04) | >.99 | .44 |
N/A = not applicable.