Table 4.
Estimates of Hazard Ratio for Efficacy Outcomes Measures According to Systolic Blood Pressure (SBP) Treatment Group for Older and Younger Participants
| Outcome | ≥75 |
<75 |
||||||
|---|---|---|---|---|---|---|---|---|
| Higher SBP (130–149 mmHg) | Lower SBP (<130 mmHg) | HR (95% CI) | P-Value | Higher SBP (130–149 mmHg) | Lower SBP (<130 mmHg) | HR (95% CI) | P-Value | |
|
|
|
|||||||
| n (%/p-y) | n (%/p-y) | |||||||
| Stroke | ||||||||
| All | 26 (3.07) | 27 (3.07) | 1.01 (0.59–1.73) | .98 | 126 (2.72) | 98 (2.09) | 0.77 (0.59–1.01) | .06 |
| Ischemic or unknown | 19 (2.24) | 24 (2.73) | 1.23 (0.67–2.24) | .50 | 112 (2.41) | 88 (1.88) | 0.78 (0.59–1.03) | .08 |
| Intracranial hemorrhage | 7 (0.83) | 3 (0.34) | 0.41 (0.11–1.59) | .20 | 14 (0.16) | 10 (0.10) | 0.71 (0.32–1.60) | .41 |
| Disabling or fatal | 17 (2.01) | 7 (0.80) | 0.40 (0.17–0.96) | .04 | 32 (0.69) | 33 (0.71) | 1.03 (0.63–1.67) | .91 |
| Myocardial infarction | 6 (0.69) | 5 (0.53) | 0.77 (0.23–2.52) | .66 | 34 (0.70) | 31 (0.64) | 0.91 (0.56–1.48) | .71 |
| Death | ||||||||
| All | 40 (4.53) | 37 (3.89) | 0.83 (0.53–1.29) | .41 | 61 (1.24) | 69 (1.40) | 1.13 (0.80–1.59) | .49 |
| Vasculara | 17 (1.93) | 8 (0.84) | 0.42 (0.18–0.98) | .05 | 24 (0.49) | 28 (0.57) | 1.17 (0.68–2.01) | .58 |
| Nonvascular | 15 (1.70) | 18 (1.89) | 1.08 (0.54–2.14) | .83 | 20 (0.41) | 22 (0.45) | 1.10 (0.60–2.01) | .77 |
| Uncertain | 8 (0.91) | 11 (0.16) | 1.22 (0.49–3.03) | .67 | 17 (0.34) | 19 (0.38) | 1.11 (0.58–2.14) | .75 |
a
Interaction between SBP target group and age, P = .049.
p-y = person-year.