Table 3.
Association analyses between HLA and number of islet autoantibodies (GADA, IA-2A, and ZnT8A)
| Number of islet autoantibodies | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 1 |
2 |
3 |
|||||||
| OR | CI | P | OR | CI | P | OR | CI | P | |
| DR4(01)-DQ8 | 1.73 | 1.18–2.55 | 0.005 | 1.99 | 1.38–2.87 | 0.005 | 2.09 | 1.45–3.00 | 8.5 × 10−5 |
| DR4(04)-DQ8 | 1.06 | 0.56–1.99 | 0.857 | 1.25 | 0.70–2.23 | 0.444 | 1.88 | 1.08–3.20 | 0.26 |
| DR3(01)-DQ2 | 1.60 | 1.17–2.18 | 0.003 | 1.40 | 1.04–1.90 | 0.028 | 1.23 | 0.90–1.68 | 0.194 |
| DQ2/DQ8 | 2.05 | 1.31–3.20 | 0.002 | 1.92 | 1.24–2.96 | 0.004 | 1.84 | 1.19–2.86 | 0.006 |
| A*2402 | 0.98 | 1.68–1.41 | 0.917 | 0.63 | 0.44–0.92 | 0.015 | 0.57 | 0.39–0.83 | 0.003 |
Significance levels are calculated from multinomial regression using 0 autoantibodies as baseline, and including age or age at onset (but not both), duration, and race/ethnicity as covariates.