Table 8.
Association of thyroid autoimmunity and thyroid disease with HLA alleles
| TPO−TD− (7,450)* | TPO+TD+ (822)* | TPO+TD− (2,088)* | TPO-TD+ (172)* | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| HLA allele | % (n) | % (n) | P | OR (95% CI) | % (n) | P | OR (95% CI) | % (n) | P | OR (95% CI) |
|
A*2402 |
12.0 (893) |
7.3 (60) |
<0.0001 |
0.59 (0.44–0.80) |
10.6 (222) |
0.139 |
0.88 (0.74–1.04) |
11.6 (20) |
>0.5 |
1.02 (0.64–1.62) |
|
DRB1*0101† |
7.3 (545) |
3.9 (32) |
<0.001 |
0.51 (0.34–0.77) |
4.4 (92) |
1E-05 |
0.58 (0.45–0.74) |
11.0 (19) |
>0.1 |
1.49 (0.91–2.44) |
|
DRB1*0404‡ |
4.9 (362) |
7.8 (64) |
<0.0001 |
1.78 (1.31–2.43) |
8.6 (179) |
5E-09 |
1.87 (1.51–2.30) |
5.8 (10) |
>0.3 |
1.48 (0.70–2.66) |
|
DQB1*0301 |
4.1 (302) |
5.7 (47) |
<0.05 |
1.43 (1.03–2.00) |
6.5 (136) |
7E-06 |
1.87 (1.30–2.00) |
6.4 (11) |
>0.2 |
1.43 (0.81–2.53) |
| DPB1*0201 | 14.0 (1,045) | 19.6 (161) | <0.0001 | 1.50 (1.22–1.84) | 17.6 (367) | 3E-04 | 1.30 (1.23–1.49) | 22.7 (39) | <0.0001 | 1.95 (1.35–2.81) |
*Data in parentheses are number of alleles in each group.
†Haplotype DRB1*0101-DQA1*0101-DQB1*0501.
‡Haplotype DRB1*0404-DQA1*0301-DQB1*0302.