Table 9.
Association of thyroid autoimmunity with HLA alleles in NHWs
| TPO− (7,622)* |
TPO+ (2,910)* |
TD− (9,918)* |
TD+ (1,030)* |
|||||
|---|---|---|---|---|---|---|---|---|
| HLA allele | % (n) | % (n) | P | OR (95% CI) | % (n) | % (n) | P | OR (95% CI) |
| A*2402 | 12.0 (913) | 6.3 (183) | 0.006 | 0.80 (0.68–0.94) | 11.7 (1,159) | 8.4 (87) | 0.006 | 0.72 (0.56–0.92) |
| DRB1*0101† | 7.4 (564) | 4.3 (124) | <0.001 | 0.55 (0.44–0.68) | 6.7 (661) | 5.2 (54) | >0.1 | 0.78 (0.57–1.06) |
| DRB1*0404‡ | 4.9 (372) | 8.3 (243) | <0.0001 | 1.84 (1.52–2.23) | 5.7 (565) | 7.8 (80) | <0.005 | 1.45 (1.12–1.88) |
| DQB1*0301 | 4.1 (313) | 6.3 (183) | <0.0001 | 1.52 (1.26–1.84) | 4.6 (459) | 5.9 (61) | >0.1 | 1.23 (0.94–1.61) |
| DPB1*0201 | 14.2 (1,084) | 18.1 (528) | <0.0001 | 1.31 (1.16–1.49) | 14.9 (1,480) | 19.8 (204) | <0.0001 | 1.37 (1.14–1.63) |
*Data in parentheses are number of alleles in each group.
†Haplotype DRB1*0101-DQA1*0101-DQB1*0501.
‡Haplotype DRB1*0404-DQA1*0301-DQB1*0302.