Table 4.

Haplotype and genotype HLA association and frequency comparison between healthy control subjects and patients with double autoimmunity, T1D only, or CeD only

	Freq. control subjects	T1D+CeD/CeD				T1D+CeD/T1D
		Freq. T1D+CeD	Freq. CeD only	OR (95% CI)	P	Freq. T1D+CeD	Freq. T1D only	OR (95% CI)	P
Haplotype
DQ2.5	0.14	0.520	0.446	1.035 (0.860, 1.249)	0.972	0.446	0.318	1.442 (1.189, 1.748)	0.0003
DQ2.2	0.094	0.047	0.155	0.255 (0.173, 0.374)	0.422	0.046	0.040	1.201 (0.793, 1.821)	0.381
DQ8	0.1	0.350	0.064	5.086 (3.883, 6.662)	0.163	0.346	0.392	0.939 (0.779, 1.131)	0.520
Other	0.663	0.157	0.260	0.467 (0.366, 0.595)	0.500	0.163	0.249	0.660 (0.530, 0.821)	0.0001
Genotype
DQ2.5/DQ2.5	0.020	0.176	0.192	0.99 (0.96, 1.02)	0.914	0.168	0.066	1.20 (1.14, 1.26)	0.005
DQ2.5/DQ2.2	0.032	0.039	0.232	0.84 (0.82, 0.87)	7.29E-4	0.039	0.017	1.16 (1.06, 1.27)	0.242
DQ2.5/DQ8	0.027	0.350	0.067	1.47 (1.41, 1.53)	3.31E-10	0.350	0.377	0.98 (0.95, 1.01)	0.681
DQ2.5/other	0.184	0.150	0.357	0.87 (0.85, 0.90)	1.9E-3	0.168	0.112	1.07 (1.03, 1.11)	0.688
DQ2.2/DQ2.2	0.012	0.005	0.004	1.03 (0.83, 1.28)	0.905	0.004	0.002	1.18 (0.88, 1.58)	0.169
DQ2.2/DQ8	0.022	0.035	0.012	1.22 (1.10, 1.36)	0.189	0.033	0.036	0.98 (0.92, 1.06)	0.908
DQ2.2/other	0.111	0.012	0.059	0.87 (0.82, 0.92)	0.129	0.010	0.025	0.91 (0.83, 0.99)	0.326
DQ8/DQ8	0.009	0.083	0.010	1.6 (1.46, 1.74)	4.20E-4	0.083	0.078	1.00 (0.96, 1.05)	0.886
DQ8/other	0.135	0.148	0.031	1.40 (1.32, 1.49)	1.46E-4	0.143	0.216	0.94 (0.91, 0.97)	0.175
Other/other	0.449	0.002	0.036	0.85 (0.79, 0.92)	0.166	0.002	0.072	0.84 (0.80, 0.89)	0.028

Freq., frequency.