Supplementary Table 2.
Distribution of combined genotypes of the g.46438521G>C – NEIL1 and c.–1370T>A – POLG polymorphisms and odds ratio (OR) with 95% confidence interval (95% CI) in patients with Fuchs endothelial corneal dystrophy (FECD) and controls.
| Combined genotypes | Controls (n=353) | FECD (n=250) | Crude OR (95% CI) | p | Adjusted OR* (95% CI) | p |
|---|---|---|---|---|---|---|
| Number (frequency) | ||||||
| C/C – A/A | 14 (0.04) | 9 (0.04) | 0.90 (0.38–2.12) | 0.817 | 0.81 (0.29–2.29) | 0.691 |
| C/C – A/T | 30 (0.08) | 25 (0.10) | 1.20 (0.68–2.09) | 0.529 | 1.25 (0.67–2.32) | 0.486 |
| C/C – T/T | 2 (0.01) | 1 (0.01) | 0.70 (0.06–7.82) | 0.776 | 0.71 (0.04–11.14) | 0.807 |
| C/G – A/A | 57 (0.16) | 30 (0.12) | 0.71 (0.44–1.14) | 0.155 | 0.85 (0.49–1.47) | 0.562 |
| C/G – A/T | 140 (0.40) | 109 (0.44) | 1.17 (0.85–1.63) | 0.333 | 1.34 (0.94–1.96) | 0.133 |
| C/G – T/T | 6 (0.02) | 5 (0.02) | 1.18 (0.36–3.91) | 0.786 | 1.56 (0.42–5.75) | 0.502 |
| G/G – A/A | 27 (0.08) | 14 (0.06) | 0.72 (0.37–1.39) | 0.327 | 0.40 (0.17–0.95) | 0.039 |
| G/G – A/T | 70 (0.20) | 54 (0.22) | 1.11 (0.74–1.66) | 0.596 | 0.97 (0.60–1.56) | 0.906 |
| G/G – T/T | 7 (0.02) | 3 (0.01) | 0.60 (0.15–2.34) | 0.463 | 0.33 (0.07–1.60) | 0.170 |
p values <0.05 along with corresponding ORs are in bold;
*
OR adjusted for co-occurrence of visual impairment, sex, age and family history for FECD.