Supplementary Table 7.
Distribution of combined genotypes of the c.2285T>C – PARP-1 and c.1196A>G – XRCC1 polymorphisms and odds ratio (OR) with 95% confidence interval (95% CI) in patients with Fuchs endothelial corneal dystrophy (FECD) and controls.
| Combined genotypes | Controls (n=353) | FECD (n=250) | Crude OR (95% CI) | p | Adjusted OR* (95% CI) | p |
|---|---|---|---|---|---|---|
| Number (frequency) | ||||||
| A/A – A/A | 52 (0.15) | 48 (0.19) | 1.47 (0.94–2.26) | 0.087 | 1.57 (0.92–2.67) | 0.096 |
| A/A – A/G | 144 (0.41) | 97 (0.39) | 1.03 (0.73–1.44) | 0.859 | 0.96 (0.65–1.43) | 0.843 |
| A/A – G/G | 43 (0.12) | 21 (0.08) | 0.58 (0.33–1.03) | 0.062 | 0.46 (0.23–0.92) | 0.029 |
| A/G – A/A | 20 (0.06) | 26 (0.10) | 1.29 (0.68–2.46) | 0.436 | 1.58 (0.75–3.32) | 0.230 |
| A/G – A/G | 74 (0.21) | 46 (0.18) | 0.80 (0.52–1.22) | 0.293 | 0.86 (0.53–1.40) | 0.549 |
| A/G – G/G | 20 (0.06) | 12 (0.05) | 1.13 (0.55–2.30) | 0.744 | 1.18 (0.51–2.74) | 0.705 |
| G/G – A/A | 0 (0.00) | 0 (0.00) | – | – | – | – |
| G/G – A/G | 0 (0.00) | 0 (0.00) | – | – | – | – |
| G/G – G/G | 0 (0.00) | 0 (0.00) | – | – | – | – |
p values <0.05 along with corresponding ORs are in bold;
*
OR adjusted for co-occurrence of visual impairment, sex, age and family history for FECD.