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p38 activation is required for interleukin-17 (IL-17) release in patients with relapsing–remitting multiple sclerosis (RR-MS): FACS-sorted CD4+ CD45RA+ CD27+ naive T cells isolated from patients with RR-MS were polarized into T helper type 17 (Th17) in the presence or absence of BIRB796. The expression of IL-17 was assessed by flow cytometry (a) and by ELISA (b). Error bars represent the SE from the mean of three distinct experiments. **P < 0·01.
