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. 2015 Aug 6;106(9):1103–1110. doi: 10.1111/cas.12731

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© 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Antitumor and protumor effects of IL-27 depending on the type of cells that IL-27 stimulates and the tumor context. CTL, cytotoxic T lymphocyte; DC, dendritic cell; EBI3, Epstein–Barr virus-induced gene 3; gp, glycoprotein; IFN, interferon; IL, interleukin; NK, natural killer; PD-L1, programmed death ligand 1; R. receptor; STAT, signal transducer and activator of transcription; Th, helper T; Tim-3, T-cell immunoglobulin and mucin domain-3; Tr1, IL-10-producing regulatory T; Treg, regulatory T.