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Effect of ghrelin administration on colonic carcinogenesis in the azoxymethane (AOM)/dextran sodium sulfate (DSS) model. (a) Number of tumors (mean ± SEM) was significantly reduced in the ghrelin administration group (ghrelin, n = 11) compared to the control group (saline, n = 9). *P < 0.0001. (b) Spleen weight relative to body weight (mean ± SEM) was modestly reduced by ghrelin treatment (P = 0.08).
