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. 2015 Jul 14;106(9):1130–1136. doi: 10.1111/cas.12725

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© 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Expression of ghrelin, growth hormone secretagogue receptor (GHSR) and pro-inflammatory cytokines in colon tissue of mice after dextran sodium sulfate (DSS) treatment (2% in drinking water, 7 days). (a) RT-PCR analysis of extracts from proximal (pLI) and distal (dLI) colon tissue of mice without (saline) or with ghrelin administration. Data from three mice are indicated for each group. (b) Quantification of pro-inflammatory cytokine mRNA levels by real-time RT-PCR in proximal colon tissue (n = 5 for each group). *P < 0.05. (c) Histological analysis of distal colon on day 7 of DSS treatment. Representative colon tissues with ulcers of similar sizes from control and ghrelin-treated (ghrelin i.p.) mice are shown. Immunostaining photos for macrophage marker (F4/80) and neutrophil marker (MPO) are shown in the lower right panel. Bar, 100 μm.