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. 2015 Sep 1;106(9):1143–1152. doi: 10.1111/cas.12730

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© 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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In vivo evaluation of hepatic fibrosis in Pdgf-c Tg mice injected with locked nucleic acid (LNA)-antimiR-214. (a) Experimental design: Pdgf-c Tg mice at 9 weeks of age were injected with saline, LNA-antimiR-control or LNA-antimiR-214 via the tail vein twice (50 μg each; n = 5). Three days after the second injection, the mice were killed for evaluation. (b) In situ hybridization of miR-214 in wild-type (WT) and Pdgf-c Tg liver injected with LNA-antimiR-control or LNA-antimiR-214. (c) Macroscopic findings of WT and Pdgf-c Tg liver injected with saline, LNA-antimiR-control or LNA-antimiR-214 (upper). Azan staining (2nd) and immunohistochemical staining of collagen 1 (3rd) and desmin (bottom) at sacrifice are shown.