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. 2015 Sep 1;106(9):1143–1152. doi: 10.1111/cas.12730

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© 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Repeated injection of locked nucleic acid (LNA)-antimiR-214 and tumor incidence in Pdgf-c Tg mice. (a) Pdgf-c Tg or WT mice at 32 weeks of age were injected repeatedly with LNA-antimiR-214, LNA-antimiR-control or saline via the tail vein for a total of six times. One week after the final injection, the mice (each group = 6) were killed. (b) Gross appearance of livers from Pdgf-c Tg or WT mice injected repeatedly with LNA-antimiR-214, LNA-antimiR-control or saline (n = 6). (c) Evaluation of fibrosis, tumors, albumin (mRNA) and serum AST in the liver of Pdgf-c Tg mice injected repeatedly with LNA-antimiR-214, LNA-antimiR-control, or saline (n = 6).