TABLE 4.
Food intake, serum biochemistry, liver weight, and liver lipid content in C57BL/6J mice fed HFD or HFD + luteolin diets for 57 days
Results are mean ± S.E. (n = 8). Values within a row without a common letter differ significantly (p < 0.05).
| HFD | HFD + 0.6% luteolin | HFD + 1.5% luteolin | |
|---|---|---|---|
| Food intake (g/mouse/day) | 2.85 ± 0.03 | 2.79 ± 0.07 | 2.84 ± 0.11 |
| Serum | |||
| Aspartate aminotransferase (IU/liter) | 76.9 ± 6.6 | 77.6 ± 9.0 | 53.4 ± 6.8 |
| Alanine aminotransferase (IU/liter) | 40.0 ± 3.5 | 41.9 ± 6.3 | 25.0 ± 5.1 |
| Glucose (mg/dl) (day 35) | 281 ± 11.3A | 246 ± 13.6AB | 215 ± 14.2B |
| Insulin (ng/dl) | 9.47 ± 1.37A | 4.90 ± 0.68B | 4.52 ± 0.90B |
| NEFA (milliequivalents/liter) | 1.00 ± 0.06 | 0.90 ± 0.06 | 0.87 ± 0.05 |
| Total bile acid (μmol/liter) | 50.1 ± 4.2 | 58.0 ± 6.5 | 40.3 ± 4.7 |
| Cholesterol (mg/dl) | |||
| Total | 205 ± 8.8A | 201 ± 4.5A | 171 ± 18B |
| CM | 0.42 ± 0.13 | 0.36 ± 0.04 | 0.34 ± 0.12 |
| VLDL | 2.38 ± 0.37A | 1.97 ± 0.42AB | 1.53 ± 0.41B |
| LDL | 56.0 ± 1.9A | 54.4 ± 5.3A | 37.8 ± 10.4B |
| HDL | 146 ± 6.6A | 145 ± 1.8AB | 132 ± 9.4B |
| Triglyceride (mg/dl) | |||
| Total | 24.7 ± 4.4A | 20.3 ± 2.5AB | 16.5 ± 4.6B |
| CM | 3.02 ± 0.81 | 2.58 ± 0.43 | 2.77 ± 1.00 |
| VLDL | 10.3 ± 1.82 | 9.03 ± 1.66 | 8.28 ± 1.97 |
| LDL | 9.32 ± 1.83A | 7.09 ± 1.21AB | 4.48 ± 1.33B |
| HDL | 2.13 ± 0.58A | 1.57 ± 0.52AB | 0.95 ± 0.47B |
| Liver | |||
| Weight (g) | 2.18 ± 0.10A | 2.20 ± 0.19A | 1.59 ± 0.12B |
| Triglyceride (mg/g) | 916 ± 119A | 910 ± 70A | 409 ± 109B |
| Cholesterol (mg/g) | 7.38 ± 0.24 | 6.43 ± 0.45 | 6.20 ± 0.36 |