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Effect of mutations on the binding affinity of A-CAT for mant-ATP
| Mutation | Kd |
|---|---|
| μm | |
| WT | 4.8 ± 0.6 |
| R592L | 15 ± 2 |
| K645R | >300 |
| D663A | 3.2 ± 0.9 |
| E713A | >300 |
| E713D | >300 |
| L716S | 60 ± 10 |
| F720S | 6.0 ± 0.2 |
| K722N | 9 ± 1 |
| D756A | 2.2 ± 0.9 |
| Q758A | 6.6 ± 0.6 |
| D766S | 3.9 ± 0.8 |
| Q768A | 5.0 ± 0.6 |
