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Proposed model for the molecular basis of the functional cooperation between motif 2/motif 3 and the IVVY motif. X, the protein binding to the IVVY motif to mediate osteoclast lineage commitment; Y, the TRAF protein binding to motif 2; Z, the TRAF protein binding to motif 3; dashed circle, the proposed formation of the signaling complex by proteins X, Y, and Z. Black arrows highlight the unidirectional nature of the functional cooperation between motif 2/motif 3 and the IVVY motif.
