Fig. 5.
Bscl2 deletion in mature adipocytes regulates food intake and energy expenditure. Food intake (A), O2 consumption (B), heat production (C), and RER (D) in Ctrl and Ad-mKO mice 3 weeks (3w) after TAM-induced Bscl2 deletion (n = 8 per group). Food intake (E), heat production (F), and RER (G) in Ctrl and Ad-mKO mice 12 weeks after TAM treatment (n = 6). H. Plasma leptin levels in 4 h-fasted Ctrl and Ad-mKO mice 12 days (12d) and 12 weeks (12w) after TAM injection (n = 6–8). Energy expenditure (EE) (I) and RER (J) in response to NE stimulation in Ctrl and Ad-mKO mice 12 weeks after TAM injection (n = 6–7). *P < 0.05, **P < 0.005.