TABLE 1.
Demographic and clinical characteristics at baseline, lipid profile and CSF variable values at disease onset
| Mean ± SDa | Reference Rangeb | |
| Demographic characteristics | ||
| Sample size (n) | 154 | — |
| Female (%) | 67 | — |
| Age (years) | 29.5 ± 8.2 | — |
| EDSS | 1.71 (0.67) | — |
| MRI Characteristics | ||
| CEL number | 1.07 ± 3.4 | — |
| T2-LV (cm3) | 5.15 ± 6.44 | — |
| Brain volume (cm3) | 1,505 ± 72 | — |
| Gray matter volume (cm3) | 791 ± 47 | — |
| Lipid profile characteristics | ||
| HDL-C (mg/dl) | 70.3 ± 19.0 | 40–83 |
| LDL-C (mg/dl) | 134 ± 40.1 | 57–189 |
| TC (mg/dl) | 204 ± 52.9 | 133–234 |
| Triglycerides (mg/dl) | 110 ± 50.9 | 37–321 |
| ApoA-I (mg/dl) | 158 ± 40.6 | 115–224 |
| ApoA-II (mg/dl) | 37.3 ± 8.65 | 25–35 |
| ApoB (mg/dl) | 73.9 ± 23.5 | 60–130 |
| ApoE (mg/dl) | 3.28 ± 1.05 | 3.3–6.1 |
| CRP (mg/l) | 2.77 ± 4.40 | <2.5 |
| CSF variable characteristics | ||
| CSF-leukocytes (in 3 mm3) | 26.5 ± 34.1 | <12 |
| CSF-total protein (mg/l) | 345 ± 119 | 150–450 |
| CSF-albumin (mg/l) | 217 ± 86 | 120–300 |
| Albumin quotient | 4.75 ± 1.84 | ≤6.5 if age <40 years, ≤8.0 if age ≥40 years |
| CSF-restricted total OCBs | 12.1 ± 5.1 | Not available |
| CSF-restricted total alkaline OCBs | 8.33 ± 3.7 | Not present |
| IgG index | 0.892 ± 0.39 | <0.65 |
| IgG quotient | 4.21 ± 2.3 | — |
| IgM index | 0.251 ± 0.32 | — |
| IgM quotient | 1.11 ± 1.1 | — |
a
All continuous variables (age, disease duration, T2-LV, and T1-LV) are mean ± SD. For the ordinal EDSS, the median (interquartile range) is given.
b
Reference range provided by diagnostic reagent kit manufacturers or clinical laboratory.