Figure 5.

Flux of the different formulations after pressure filtration expressed as mean ± standard deviation (g/s).

Notes: A and B at the end of the legend refer to the method employed for the vesicles preparation, method A or method B, respectively. For each formulation, the flux was performed in triplicate (n=3). Statistical analysis: One Way Anova with All Pairwise Multiple Comparison Procedures; means with different letters (a,b,c) and different numbers are significantly different (P<0.05). The letters are also numerated according to each group.

Abbreviations: E caf, caffeine-loaded ethosomes; empty E, empty ethosomes; empty TE NaCo, empty sodium cholate transethosomes; empty TE span, empty Span 20 transethosomes; empty T Naco, empty sodium cholate transfersomes; empty T span, empty Span 20 transfersomes; E vitE, vitamin E-loaded ethosomes; T caf NaCo, caffeine-loaded sodium cholate transfersomes; T caf span, caffeine-loaded Span 20 transfersomes; TE caf NaCo, caffeine-loaded sodium cholate transethosomes; TE caf span, caffeine-loaded Span 20 transethosomes; TE vitE NaCo, vitamin E-loaded sodium cholate transethosomes; T vitE NaCo, vitamin E-loaded sodium cholate transfersomes.