Table 1.
Basic Information of the 15 studies included in the meta-analysis
| Study | Country | Surgery | Number of cases (Sevoflurane/propofol, n) | Anesthesia | |||
|---|---|---|---|---|---|---|---|
| Sevoflurane group | Propofol group | ||||||
| Induction | Maintenance | Induction | Maintenance | ||||
| Gravel et al. [10] | Canada | CABG (on-pump and off-pump) | 15/15 | 4 % sevoflurane + 0.5 μg/kg sufentanil | 0.5-2MAC sevoflurane + 0.5 μg/kg/h sufentanil | 1 mg midazolam + 0.5 μg/kg sufentanil | 40-150 μg/kg/min propofol + 0.5 μg/kg/h sufentanil |
| De Hert et al. [11] | Belgium | CABG (on-pump) | 10/10 | 4 % sevoflurane + 0.4 μg/kg/min remifentanil | 0.5–2 % sevoflurane + 0.3–0.6 μg/kg/min remifentanil | 2 mg/ml propofol + 0.4 μg/kg/min remifentanil | 2-4 mg/ml propofol + 0.3-0.6 μg/kg/min remifentanil |
| Conzen et al. [12] | Germany | CABG (off-pump) | 10/10 | 0.3 mg/kg etomidate | 2 % sevoflurane | 2 μg/ml propofol | 2-3 μg/ml propofol |
| De Hert et al. [13] | Belgium | CABG (on-pump) | 15/15 | 2–8 % sevoflurane + 0.4 μg/kg/min remifentanil | 0.5–2%sevoflurane + 0.3–0.6 μg/kg/min remifentanil | 2 μg/ml propofol + 0.4 μg/kg/min remifentanil | 2-4 μg/ml propofol + 0.3-0.6 μg/kg/min remifentanil |
| De Hert et al. [14] | Belgium | CABG (on-pump) | 80/80 | 0.1 mg/kg midazolam + 0.4 μg/kg/min remifentanil | 0.5–2 % sevoflurane + 0.2–0.4 μg/kg/min remifentanil | 2 μg/mlpropofol + 0.4 μg/kg/min remifentanil | 2-4 μg/ml propofol + 0.2-0.4 μg/kg/min remifentanil |
| Parker et al. [15] | Australia | CABG (on-pump) | 118/118 | 10 μg/kg fentanyl + 0.1 mg/kg diazepam + 0.15 mg/kg pancuronium bromide | 1–4 % sevoflurane | 10 μg/kg fentanyl + 0.1 mg/kg diazepam + 0.15 mg/kg pancuronium bromide | 1-8 μg/ml propofol |
| Kawamura et al. [16] | Japan | CABG (on-pump) | 13/10 | 10 μg/kg fentanyl + 2–3 mg midazolam | 0.5 %-1 % sevoflurane + 30 μg/kg fentanyl | 10 μg/kg fentanyl + 2–3 mg midazolam | 2-8 mg/kg/h propofol + 30 μg/kg fentanyl |
| Cromheecke et al. [17] | Belgium | AVR | 15/15 | 0.5–1 % sevoflurane + 0.4 μg/kg/min remifentanil | 0.5–1 % sevoflurane + 0.2–0.4 μg/kg/min remifentanil | 2 μg/ml propofol + 0.4 μg/kg/min remifentanil | 2-4 μg/mlpropofol + 0.2-0.4 μg/kg/min remifentanil |
| Lorsomradee et al.[18] | Belgium | CABG (on-pump) | 160/160 | sevoflurane + 0.2–0.4 μg/kg/min remifentanil | 0.5–2 % sevoflurane + 0.2–0.4 μg/kg/min remifentanil | 2 μg/ml propofol + 0.2-0.4 μg/kg/min remifentanil | 2-4 μg/ml propofol + 0.2-0.4 μg/kg/min remifentanil |
| Law-Koune et al. [19] | France | CABG (off-pump) | 9/9 | 8 % sevoflurane + 2 ng/mL remifentanil | sevoflurane(BIS 40–60) + remifentanil | 2 μg/ml propofol + 2 ng/mL remifentanil | propofol(BIS 40–60) + remifentanil |
| Lucchinetti et al. [20] | Switzerland | CABG (off-pump) | 10/10 | fentanyl + midazolam | sevoflurane + fentanyl + midazolam | fentanyl + midazolam | propofol + fentanyl + midazolam |
| Yildirim et al. [21] | Turkey | CABG (on-pump) | 20/20 | 2–8 % sevoflurane + 0.4 μg/kg/min remifentanil | 0.5–2 % sevoflurane + 0.3–0.6 μg/kg/min remifentanil | 0.2 μg/ml propofol + 0.4 μg/kg/min remifentanil | 2-4 mg/mlpropofol + 0.3-0.6 μg/kg/min remifentanil |
| Ballester et al. [22] | Spain | CABG (off-pump) | 18/20 | 0.1 mg/kg midazolam + 2–4 μg/kg fentanyl + 0.3 mg/kg etomidate | 1.5–2.5 % sevoflurane | 0.1 mg/kg midazolam + 2–4 μg/kg fentanyl + 0.3 mg/kg etomidate | 6-8 mg/kg/h propofol |
| Jovic et al. [23] | Serbian | AVR | 11/11 | 0.3 mg/kg midazolam + 0.7–1 mcg/kg sufentanil | 0.1–0.2 mcg/kg/h sevoflurane | 1–1.5 mg/kg propofol + 0.7–1 mcg/kg sufentanil | 6-10 mg/kg/h propofol + 0.1-0.2 mcg/kg/h sufentanil |
| Suryaprakash et al. [24] | India | CABG (off-pump) | 48/39 | 5–10 μg/ kg fentanyl + 0.02 mg/kg midazolam | 1–2 % sevoflurane + 1 μg/kg/h fentanyl | 5–10 μg/ kg fentanyl + 0.02 mg/kg midazolam | 2-4 mg/kg/h propofol + 1 μg/kg/h fentanyl |
CABG coronary artery bypass graphing, AVR aortic valve replacement