Table 1.

Performance of different cleaning approaches when there is no genuine correlation between genes (based on 1000 simulation runs)

Method	Raw	BC	BC+QN	RUV-random
FN2	0.126	0.124	0.125	0.001

The performance was measured using a measure similar to the squared Frobenius norm (FN²) measure (explained in the text), which should be close to 0. All parameter choices and details of the simulation can be found in Additional file 1. All standard deviations were <0.001