Table 2.
Viremia and brain titers from mice inoculated with 100 pfu of either wild-type WNV or P38G/T116I/N480H mutant virus via the intraperitoneal route.
| Day | NY99 ip serum (log10 pfu/mL) |
Brain titer (log10 pfu/brain) |
P38G/T116I ip serum (log10 pfu/mL) |
Brain titer (log10 pfu/brain) |
|---|---|---|---|---|
| 1 | 4.1±0.9 | – a | 2.5±0.3 | – |
| 2 | 5.0±0.5 | – | 3.1±0.2 | – |
| 3 | 2.5±0.3 | – | 2.3±0.6 | – |
| 4 | 2.1±0.1 | 4.3±0.3 | 2.0b | – |
| 5 | – | 5.1±0.8 | – | – |
| 6 | – | 6.8±0.6 | – | – |
a
No virus detected. The limits of detection were 1.7 log10pfu/mL in the serum and 2.7 log10pfu/brain.
b
Only one of three mice had detectable infectivity.