Table 2. Standard single stranded DNA fragments with their corresponding base adducted in comparison with the hot spot database13 a .
Standard ss-DNA | Sequence | LC-MS/MS DATA |
Common Hot Spots from Database13–15,18 | |
Base adducted | Codon | |||
Fragment 1 | GGCGGCATG | GG*CGGCATG | 244 c | 244 c , 245 b e |
GGCGGCATG* | 246 | 244 c , 245 b e | ||
Fragment 2 | AACCGGAGGCCCATCCTCA | AACCGGAGG*CCCATCCTCA | 249 b c | 248 b c d e f , 249 b c |
Complementary strands | ||||
Fragment 3 | GTGAGGATGGGCCTCCGGTTCATG | GTGAG*GATGGGCCTCCGGTTCATG | ||
Fragment 4 | CCGCCCATG | CCG*CCCATG | ||
CCGCCCA*TG | ||||
CCGCCCATG* |
aPossible cancers due to BPDE.
bNon small cell lung cancer.
cSmall cell lung cancer.
dHead and neck cancer.
eColorectal cancer.
fSkin cancer.