Table 3. Meta-Analysis Results of Publicly Available Microarray Datasets.
| Top predicted phenotypes | # Shared Relations * | Score † |
|---|---|---|
| Endothelial cell migration | 12 | 136 |
| Vasculogenesis | 11 | 103 |
| Angiogenesis | 20 | 86 |
| Lymphangiogenesis | 8 | 70 |
| Neovascularization | 11 | 57 |
| Endothelial cell proliferation | 9 | 55 |
| Platelet aggregation | 7 | 55 |
| Cell adhesion | 15 | 52 |
| Top predicted diseases | ||
| Vascular disease | 12 | 59 |
| Non-small cell lung carcinoma | 14 | 55 |
| Osteoarthritis | 11 | 46 |
| Preeclampsia | 10 | 42 |
| Pancreatic cancer | 12 | 40 |
| Diabetic nephropathy | 9 | 39 |
| Colorectal cancer | 14 | 39 |
* Using the 25 genes with MEDLINE entries that are most highly correlated with PEAR1 expression (see S2 Table), predicted phenotypes, diseases, and genes were identified with Global Microarray Meta-Analysis (GAMMA), and the number of shared relations represents how many of the 25 genes were related to term (left column).
†Score reflects the relative enrichment of observed connections within the analyzed network relative to a random network with the same number of connections per gene, enabling prediction to be prioritized [15].