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. 2015 Sep 25;11(9):e1005498. doi: 10.1371/journal.pgen.1005498

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© 2015 Loukola et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 3 — (A) In the GWAS meta-analysis a minimum p-value of 5.77E-86 was obtained for rs56113850, in intron 4 of CYP2A6. (B) Analyses conditioned on the top-SNP (rs56113850) revealed rs113288603 as a second independent genome-wide significant signal (p_cond = 7.03E-25). (C) Analyses conditioned on the two independent SNPs (rs56113850, rs113288603) revealed esv2663194 as a third independent genome-wide significant signal (p_cond = 9.3E-17). (D) Analyses conditioned on the three independent SNPs yielded no additional signal exceeding the genome-wide significance threshold. All plots are generated with LocusTrack [52]. LD (R²) values were obtained from the FINRISK sample (N = 19857).