Table 2.
Biopsy characteristics at diagnosis and then at each sequential surveillance biopsy; not shown are 3 8th biopsy cases and 2 9th biopsy cases.
| Characteristics | Diagnosis biopsy |
First biopsy |
Second biopsy |
Third biopsy |
Fourth biopsy |
Fifth biopsy |
Sixth biopsy |
Seventh biopsy |
|---|---|---|---|---|---|---|---|---|
| # of patients | 979 | 859 | 458 | 211 | 75 | 26 | 14 | 6 |
| Mean (SD) age at biopsy (years) |
62.0 (6.9) |
63.0 (7.0) |
64.4 (6.9) |
65.5 (6.9) |
65.5 (7.2) |
67.5 (6.8) |
66.5 (5.7) |
65.1 (6.1) |
| Mean (SD) number of months since last biopsy |
0 (0) |
12.8 (8.8) |
19.7 (8.3) |
21.1 (7.9) |
20.1 (7.8) |
20.4 (5.7) |
20.6 (5.5) |
20.1 (5.8) |
| Mean (SD) of most recent PSA |
5.5 (3.0) |
5.0 (3.3) |
5.2 (3.6) |
5.4 (3.6) |
5.5 (3.9) |
5.0 (3.8) |
5.3 (3.3) |
5.0 (4.8) |
| Median (range) of number of biopsy cores |
12 (4, 60)* |
12 (4, 60)# |
12 (4, 46) |
12 (4, 46) |
12 (4, 34) |
15 (12, 18) |
16 (12, 18) |
17 (14, 20) |
| Percent of cores positive for cancer |
||||||||
| 0 | 0 (0.0%) |
312 (36.3%) |
190 (41.5%) |
88 (41.7%) |
30 (40.0%) |
11 (42.3%) |
6 (42.9%) |
3 (50%) |
| > 0 and < 34% | 860 (87.8%) |
465 (54.1%) |
224 (48.9%) |
104 (49.3%) |
41 (54.7%) |
14 (53.9%) |
8 (57.1%) |
3 (50%) |
| ≥ 34% | 37 (3.8%) |
66 (7.7%) |
37 (8.1%) |
18 (8.85%) |
4 (5.3%) |
1 (3.9%) |
0 (0.0%) |
0 (0.0%) |
| NA | 82 (8.4%) |
16 (1.9%) |
7 (1.5%) |
1 (0.5%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
| Gleason score | ||||||||
| ≤ 6 | 979 (100%) |
732 (85.2%) |
384 (83.8%) |
166 (78.7%) |
63 (84.0%) |
23 (88.5%) |
11 (78.6%) |
6 (100.0%) |
| 7 | 0 (0.0%) |
123 (14.3%) |
70 (15.3%) |
43 (20.4%) |
10 (13.3%) |
3 (11.5%) |
2 (14.3%) |
0 (0.0%) |
| ≥ 8 | 0 (0.0%) |
4 (0.5%) |
4 (0.9%) |
2 (1.0%) |
2 (2.7%) |
0 (0.0%) |
1 (7.1%) |
0 (0.0%) |
| Outcome | ||||||||
| Progression | 0 (0.0%) |
163 (0.0%) |
104 (22.7%) |
61 (28.9%) |
19 (25.3%) |
3 (11.5%) |
3 (21.4%) |
1 (16.7%) |
| Stable | 897 (91.6%) |
684 (79.6%) |
347 (75.8%) |
149 (70.6%) |
56 (74.6%) |
23 (88.5%) |
11 (78.6%) |
5 (83.3%) |
| NA | 82 (8.4%) |
12 (1.4%) |
7 (1.5%) |
1 (0.5%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
*
5 patients with number of cores below 4; 2 patients with number of cores above 60;
#
1 patient with a missing number of cores; 19 patients with more than 60 cores.