Table 1.
Ceftaroline use in patients with infective endocarditis (IE)/complicated bacteremia due to Staphylococcus aureus resistant to methicillin, vancomycin or daptomycin.
| Daptomycin-susceptible | Daptomycin-non-susceptible (DNS) | |||||||
|
|
||||||||
| MRSAa | Author |
N
(total) |
N
(IE) |
Comment | Author |
N
(total) |
N
(IE) |
Comment |
|
| ||||||||
| Ho [6] | 5 | 1 | Jongsma [7] | 1 | 1 | |||
| Polenakovik [10] | 30 | 8 | 1 case with transient DNS VISA | |||||
| Tattevin [11] | 5 | 5 | Ceftaroline used with daptomycin in 1/5 case |
|||||
| Lin [13] | 10 | 6 | ||||||
| Fabre [12] | 29 | 15 | Ceftaroline used with TMP/SMX in 23/29 cases; used with daptomycin in 2/29 cases |
|||||
| Sakoulas [9] | 20 | 10 | Ceftaroline used with daptomycin in all 20 cases |
|||||
|
|
||||||||
| VISA | Author |
N
(total) |
N
(IE) |
Comment | Author |
N
(total) |
N
(IE) |
Comment |
|
| ||||||||
| Ho [6] | 1 | 1 | Polenakovik [10] | 1 | 1 | Case with transient DNS VISA | ||
| Sakoulas [9] | 2 | 1 | Ceftaroline used with daptomycin in both cases |
|||||
a
VISA cases not included In the MRSA category.
Abbreviations: MRSA: methicillin resistant Stop/iy/ococcus aureus; VISA: vancomycin intermediate Staphylococcus aureus; MSSA: methicillin susceptible Staphylococcus aureus; MRSE: = methicillin resistant Staphylococcus epidermidis; IE: infective endocarditis [includes definite, probable and possible cases]; TMP/SMX: trimethoprim/sulfamethoxazole.