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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Mucosal Immunol. 2015 Mar 25;8(6):1285–1296. doi: 10.1038/mi.2015.19

Figure 3. Treatment with WT-CCN1 promotes survival and mucosal repair.

Figure 3

(A) Ccn1dm/dm mice (n=10) were injected i.p. with 5 μg of WT-CCN1 or vehicle control daily for 5 days after each cycle of 5% DSS feeding and monitored for survival. *P<0.05, **P<0.01 (log-rank test). (B) Mice similarly treated except with 3.5% DSS were monitored for body weight change and (C) colon lengths (n=6–8). (D) Mucosal recovery was evaluated by H&E staining of paraffin-embedded colonic tissue. Histological scores are shown on right. Data are presented as mean ± SEM; n=3–4; *P<0.05, **P<0.01, ***P<0.001. Scale bar=100 μm.