Figure 3.
Relative changes of adenosine A1 receptor (A1R) density during sleep restriction (SR1, SR3 and SR5) and recovery sleep days (R1 and R3) compared to baseline (BL). Chronic sleep restriction produced a pattern in all brains of increased A1R receptor density throughout SR and recovery days, except on SR3. A1R density was elevated significantly on R3 in six of the 13 brain regions examined. The six brain regions shown are representative of all A1R temporal patterns observed. HDB, horizontal limb of diagonal band; MCPO, magnocellular preoptic nuclei. See Table 1 for analysis of variance (anova) and linear contrast statistics; the asterisks (*) indicate statistical significance of post-hoc comparisons to BL (P < 0.05, n = 8).