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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Microcirculation. 2015 Oct;22(7):518–527. doi: 10.1111/micc.12222

Figure 3.

Figure 3

Sex differences in NO and A2A AR-dependent coronary RH in ApoE-HFD mice. A) Summarized effect of L-NAME (NOS inhibitor, 100 μM) and SCH58261 (selective A2A AR antagonist, 1 μM) on baseline coronary flow (A) and % of inhibition (B) of isolated mouse hearts from female and male WT vs. ApoE-HFD mice (N=4 per group). C–F) Summarized effect of L-NAME and SCH58261 on coronary repayment volume (C, the absolute coronary flow, D, % of inhibition), and on repayment/debt ratio (E, the absolute coronary flow; F, % of inhibition) in WT vs. ApoE-HFD mice. *, #, and &p<0.05 vs. control, L-NAME, and SCH58261 treatment in female WT mice, respectively; $p<0.05 vs. L-NAME treatment in female ApoE-HFD mice.