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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Mol Psychiatry. 2015 Aug 11;20(10):1161–1172. doi: 10.1038/mp.2015.113

Figure 4.

Figure 4

Prepulse inhibition (PPI) was increased in Pv-mG5−/− mice. (a) PPI increased as prepulse intensity was increased (prepulse: F(2,200) = 339.37, P <0.001). PPI was increased in Pv-mG5−/− mice (genotype: F(1,100) = 6.78, P <0.05). (b) Startle magnitude was not different between control and Pv-mG5−/− mice, but habituation to the startle response was evident (block: F(1,100) = 60.43, P <0.001). (c) Increased PPI was also evident in Pv-mG5−/− mice when the electromyography (EMG) response was assessed (genotype: F(1,41) = 5.95, P <0.05; d) and occurred without alterations in the startle response (genotype: F(1,41) = 0.01, not significant (NS)). Performance was analyzed by either repeated-measures or one-way analysis of variance followed, when appropriate, by Fisher’s LSD post hoc test. Light bars reflect control mice, and dark bars reflect Pv-mG5−/− mice. Asterisk denotes difference between control and Pv-mG5−/− mice (*P<0.05, **P<0.01, ***P<0.001). Bar graphs depict means ± s.e.m.