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PBMC were cultured as in Fig 5, and after 2 days of protease treatment, conditioned media were analyzed by ELISA for (A) IL-4, (B) IL-13, (C) IL-10, and (D) IL-12. Values are mean ± SEM, n = 6. * indicates p < .05 and ** p < .01 compared to the no-protease control (paired two-tailed t-tests).
