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. 2015 Sep 25;10(9):e0138748. doi: 10.1371/journal.pone.0138748

Fig 15. Proteases induce changes in fibrocyte marker expression through activation of PAR-1 and PAR-2.

Fig 15

PBMC were cultured as in Fig 1, and after five days of treatment by PAR agonists, proteases, or proteases in the presence of PAR-1 or PAR-2 inhibitors, were analyzed as in Fig 1B. (A) CCR7 positive fibrocytes, (B) CD163 positive fibrocytes, (C) CD206 positive fibrocytes, and (D) fibronectin positive fibrocytes. Values are mean ± SEM, n = 6. * indicates p < .05 and *** indicates p < .001 compared to the no-protease control (paired two-tailed t-tests).