Table 1. Morphological and histological analysis in surviving commercial EU WT and in-house bred AUS WARP KO mice.
| Sham | MI | |||
| EU WT com (n = 4) | AUS WARP KO in-house (n = 4) | EU WT com (n = 9) | AUS WARP KO in-house (n = 13) | |
| HW / BW (mg/g) | 4.27 ±0.12 | 3.94 ± 0.18 | 4.75 ± 0.14 | 4.80 ± 0.26 |
| LW / BW (mg/g) | 6.56 ± 0.58 | 6.41 ± 0.76 | 6.64 ± 0.44 | 6.26 ± 0.34 |
| Remote | Infarct | |||
| EU WT com (n = 5) | AUS WARP KO in-house (n = 7) | EU WT com (n = 5) | AUS WARP KO in-house (n = 7) | |
| Infarct size (%) | N.A. | N.A. | 39.10 ± 2.433 | 50.93 ± 2.39 ## |
| Infarct thickness (A.U.) | N.A. | N.A. | 100.00 ± 19.50 | 79.70 ± 4.44 |
| Viable area (%) | N.A. | N.A. | 15.45 ± 0.60 | 29.29 ± 4.06 ## |
| CD45 count (cells/mm 2 ) | 26 ± 5 | 60 ± 20 | 274 ± 36** | 200 ± 55 |
| CD31 count (vessels/mm 2 ) | 1707 ± 271 | 2389 ± 456 | 118 ± 27** | 169 ± 58*** |
| Collagen deposition (%) | N.A. | N.A. | 61.17 ± 4.12 | 52.75 ± 3.24 |
| Fraction O-R thick/Y-G thin collagen fibers | N.A. | N.A. | 0.5 ± 0.05 / 0.5 ± 0.05 | 0.4 ± 0.05 / 0.6 ± 0.05 |
MI indicates myocardial infarction; EU European; AUS Australian; WT wild type; KO knock out; WARP Von Willebrand A domain related protein; com commercial; HW heart weight; BW body weight; LW lung weight; N.A. not applicable; A.U. arbitrary units; mm millimeter.
##p≤0.01 WT vs KO Infarct
**p≤0.01
***p≤0.001 Remote vs Infarct.