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. 2015 Sep 25;10(9):e0138515. doi: 10.1371/journal.pone.0138515

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© 2015 Liu et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 5 — (A) The expression of c-Myc was positively associated with that of SALL4 in Ishikawa and AN3CA cells by western blotting analysis. (B) c-Myc was a direct target of SALL4 through ChIP assay. (C) Downregulation of c-Myc by specific siRNA reduced SALL4-induced invasion in Ishikawa cells overexpressing SALL4 by transwell assay. (D)(E) Downregulation of c-Myc reduced SALL4-induced drug resistance in Ishikawa cells overexpressing SALL4 through viability assay and clone formation assay. (F) The expression of EMT-related markers and ABCB1 was assessed by western blotting in Ishikawa cells. (G)(H) The mRNA levels of c-Myc, E-cadherin and N-cadherin were detected through qRT-PCR in Ishikawa cells. **P<0.01.