Table 2. Gram-positive organisms causing Peritoneal Dialysis-Related Peritonitis and their In Vitro Susceptibility Rates over 32 years.
| Methicillin-sensitive S. aureus n (% susceptible) | Methicillin-resistant S. epidermidis n (% susceptible) | Enterococcus spp. n (% susceptible) | Streptococcus spp. n (% susceptible) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P1 | P2 | P3 | P | P1 | P2 | P3 | P | P1 | P2 | P3 | P | P1 | P2 | P3 | P | |
| Ampicillin | 23 (52) | 11 (36) | 15 (47) | NS | 6 (0) | 9 (0) | 45 (0) | NS | 5 (100) | 8 (63) | 16 (69) | NS | 13 (92) | 22 (95) | 40 (93) | NS |
| Amp/Sulb | NT | 10 (90) | 15 (100) | --- | NT | 9 (0) | 45 (0) | NS | NT | NT | NT | --- | NT | 22 (100) | 36 (100) | NS |
| Cefazolin | 23 (100) | 11 (91) | 15 (100) | NS | 6 (0) | 9 (0) | 45 (0) | --- | NT | NT | NT | --- | 13 (92) | NT | NT | --- |
| Ceftriaxon | NT | 2 (50) | NT | --- | NT | 1 (0) | NT | --- | NT | NT | NT | --- | NT | 8 (100) | 39 (100) | NS |
| Vancomycin | 17 (100) | 11 (100) | 15 (100) | NS | 6 (100) | 9 (100) | 45 (100) | NS | NT | 8 (88) | 16 (81) | NS | 13 (100) | 23 (100) | 39 (100) | NS |
| Linezolid | NT | 3 (100) | 14 (100) | --- | NT | 3 (100) | 45 (100) | NS | NT | 5 (100) | 16 (100) | NS | NT | 1 (100) | 3 (100) | --- |
| Imipinem | 14 (100) | 11 (91) | 15 (100) | NS | NT | 9 (0) | 45 (0) | NS | NT | 8 (63) | 15 (73) | NS | 5 (100) | 22 (100) | 40 (100) | NS |
| Gentamicin | 23 (70) | 11 (91) | 15 (100) | <0.05* | 6 (67) | 9 (67) | 45 (56) | NS | 5 (80) | 8 (63) | 15 (53) | NS | 13 (54) | 16 (25) | 9 (44) | NS |
| Moxifloxacin | NT | NT | 14 (100) | --- | NT | NT | 45 (13) | --- | NT | NT | 15 (40) | --- | NT | NT | 35 (89) | --- |
| Levofloxacin | NT | 8 (100) | 15 (100) | NS | NT | 8 (13) | 42 (12) | NS | NT | 6 (83) | 15 (40) | NS | NT | 15 (33) | 34 (82) | <0.001 |
| Doxycycline | 23 (70) | 11 (91) | 15 (100) | <0.05* | 6 (100) | 9 (78) | 45 (84) | NS | 5 (40) | 5 (100) | 12 (58) | NS | 13 (85) | 21 (48) | 35 (63) | NS |
| Episodes | 23 | 11 | 15 | 6 | 9 | 45 | 5 | 8 | 16 | 13 | 23 | 40 | ||||
P1 = (1979–1992); P2 = period 2 (1993–2003); P3 = period 3 (2004–2014); number of antibiograms; percentage of full susceptibility; NT, not tested; Amp/Sulb, ampicillin/sulbactam,
*comparison between period 1 and period 3; NS, not significant;