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. 2015 Sep 25;10(9):e0139058. doi: 10.1371/journal.pone.0139058

Fig 7. Effect of the H29D mutation on the thermal stability of the N-terminal domains of RyR2.

Fig 7

Location of residue H29 in the three-dimensional structure of the N-terminal domains of RyR2 in the top view (A) and side view (B). The central chloride ion is shown as a sphere. Panel A also shows the relative location of the RyR2 N-terminal region within a recent RyR1 cryo-EM map. (C). Representative thermal melting curves of the WT (filled circles) and the H29D mutant (open circles) N-terminal domains of RyR2 (RyR2ABC) (n = 5).